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1. (WO2018158520) METHOD FOR PREPARING 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-YLIUM IODIDE

Pub. No.:    WO/2018/158520    International Application No.:    PCT/FR2018/050372
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Sat Feb 17 00:59:59 CET 2018
IPC: C07D 279/18
Applicants: PROVEPHARM LIFE SOLUTIONS
Inventors: FERAUD, Michel
SAYAH, Babak
QUERU, Stéphane
LAURENT, Marina
Title: METHOD FOR PREPARING 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-YLIUM IODIDE
Abstract:
Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and comprises the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.