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1. (WO2018158375) LIPOSOMES FOR INHIBITING BIOFILM FORMATION
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Pub. No.: WO/2018/158375 International Application No.: PCT/EP2018/055061
Publication Date: 07.09.2018 International Filing Date: 01.03.2018
IPC:
A61K 31/045 (2006.01) ,A61K 47/28 (2006.01) ,A61K 9/127 (2006.01) ,A61K 31/685 (2006.01) ,A61K 31/688 (2006.01) ,A61P 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
28
Steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685
one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
688
both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
COMBIOXIN SA [CH/CH]; 8 rue de la Rôtisserie 1204 Geneva, CH
Inventors:
AZEREDO DA SILVEIRA LAJAUNIAS, Samareh; CH
LAJAUNIAS, Frédéric; CH
Agent:
SPERRLE, Martin; CH
Priority Data:
17158913.802.03.2017EP
Title (EN) LIPOSOMES FOR INHIBITING BIOFILM FORMATION
(FR) LIPOSOMES POUR INHIBER LA FORMATION DE BIOFILMS
Abstract:
(EN) The present invention relates to a composition comprising, preferably consisting of, (i) a single empty liposome, wherein said single empty liposome is selected from (a) an empty liposome comprising cholesterol, wherein the amount of cholesterol is at least 30% (weight per weight), wherein preferably said empty liposome comprising, further preferably consisting of, cholesterol and sphingomyelin; or (b) an empty liposome consisting of sphingomyelin; or (ii) a mixture of empty liposomes; wherein said mixture of empty liposomes comprises, preferably consists of, at least one empty liposome selected from (a) an empty liposome comprising cholesterol, wherein the amount of cholesterol is at least 30% (weight per weight), wherein preferably said empty liposome comprising, further preferably consisting of, cholesterol and sphingomyelin; (b) an empty liposome consisting of sphingomyelin; and (c) an empty liposome comprising, preferably consisting of, phosphatidylcholine and sphingomyelin; and at least one empty liposome independently of each other selected from an empty liposome comprising, preferably consisting of, lipids or phospholipids selected from cholesterol, sphingomyelins, ceramides, phosphatidylcholines, phosphatidylethanolamines, phosphatidylserines, diacylglycerols, and phosphatidic acids containing one or two or more saturated or unsaturated fatty acids longer than 4 carbon atoms and up to 28 carbon atoms; for use in a method for preventing or reducing biofilm formation or for eradicating or reducing existing biofilm.
(FR) La présente invention concerne une composition comprenant, et de préférence comprenant uniquement, (i) un unique liposome vide, ledit liposome vide unique étant sélectionné entre (a) un liposome vide comprenant du cholestérol, la quantité de cholestérol représentant au moins 30 % en poids; de préférence ledit liposome vide comprenant, plus préférablement, constitué de cholestérol et de sphingomyéline; ou (b) un liposome vide constitué de sphingomyéline; ou (ii) un mélange de liposomes vides, ledit mélange de liposomes vides comprenant, de préférence, au moins un liposome vide choisi parmi (a) un liposome vide comprenant du cholestérol, la quantité de cholestérol représentant au moins 30 % en poids, de préférence ledit liposome vide comprenant, plus préférablement, constitué de cholestérol et de sphingomyéline; (b) un liposome vide constitué de sphingomyéline; et (c) un liposome vide comprenant, de préférence constitué de phosphatidylcholine et de sphingomyéline; et au moins un liposome vide indépendamment l'un de l'autre choisi parmi un liposome vide comprenant, de préférence constitué de, des lipides ou des phospholipides choisis parmi le cholestérol, les sphingomyélines, les céramides, les phosphatidylcholines, les phosphatidyléthanolamines, les phosphatidylsérines, les diacylglycérols, et les acides phosphatidiques contenant un ou deux acides gras saturés ou insaturés plus longs que 4 atomes de carbone et jusqu'à 28 atomes de carbone; la composition étant destinée à être utilisée dans une méthode de prévention ou de réduction de la formation de biofilms ou d'éradication ou de réduction du biofilm existant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)