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1. (WO2018158349) TANDEM DIABODY FOR CD16A-DIRECTED NK-CELL ENGAGEMENT

Pub. No.:    WO/2018/158349    International Application No.:    PCT/EP2018/054989
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: C07K 16/28
A61K 39/00
Applicants: AFFIMED GMBH
Inventors: ROSS, Thorsten
FUCEK, Ivica
ELLWANGER, Kristina
WEICHEL, Michael
REUSCH, Uwe
KNACKMUSS, Stefan
RAJKOVIC, Erich
TREDER, Martin
Title: TANDEM DIABODY FOR CD16A-DIRECTED NK-CELL ENGAGEMENT
Abstract:
The invention relates to a tandem diabody specifically binding bivalently to CD16A and consisting of two polypeptide chains, wherein each polypeptide chain comprises at least four variable domains from the N-terminus to the C-terminus in the order: VH_TA-VL_CD16A-VH_CD16A-VL_TA.