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1. (WO2018158297) CHK1 INHIBITION, SYNTHETIC LETHALITY AND CANCER TREATMENT

Pub. No.:    WO/2018/158297    International Application No.:    PCT/EP2018/054896
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Mar 01 00:59:59 CET 2018
IPC: A61K 31/495
A61P 35/00
Applicants: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL
Inventors: WORKMAN, Paul
ROGERS, Rebecca Florence
CLARKE, Paul Andrew
Title: CHK1 INHIBITION, SYNTHETIC LETHALITY AND CANCER TREATMENT
Abstract:
The present invention provides a composition comprising a Checkpoint (Chk1) inhibitor for use in a method of treatment of a cancer in a mammalian subject, wherein the cancer comprises one or more cells that carry mutations in or are deficient in DNA polymerase alpha and/or DNA polymerase epsilon. Also provided is a composition comprising a Checkpoint 1 (Chk1) inhibitor for use in a method of treatment of a cancer in a mammalian subject, wherein the Chk inhibitor is administered simultaneously, separately or sequentially with an inhibitor of DNA polymerase epsilon. Related methods of treatment are also provided.