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1. (WO2018158256) NOVEL COMPOUNDS USEFUL AS POTASSIUM CHANNEL OPENERS

Pub. No.:    WO/2018/158256    International Application No.:    PCT/EP2018/054820
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Wed Feb 28 00:59:59 CET 2018
IPC: C07D 333/24
A61K 31/381
A61P 27/16
Applicants: ACOUSIA THERAPEUTICS GMBH
Inventors: BÖS, Michael
Title: NOVEL COMPOUNDS USEFUL AS POTASSIUM CHANNEL OPENERS
Abstract:
The present invention discloses novel compounds which are useful as potassium channel openers, in particular as openers of the Kv7.4 potassium channel. The novel compounds are compounds according to formula (I), wherein - n = 0 or 1, - RL is a substituent selected from the group consisting of unsubstituted or substituted cycloalkyl groups, in particular bicycloalkyl groups, unsubstituted or substituted phenyl groups, unsubstituted or substituted thienyl groups or cyclopentathienyl groups, and unsubstituted or substituted indanyl groups, which optionally contain heteroatoms, and - RR is a substituent selected from the group consisting of unsubstituted or substituted phenyl groups or unsubstituted or substituted benzyl groups, which optionally contain heteroatoms, - or a stereoisomer, a tautomer, a prodrug or a salt, preferably pharmaceutically acceptable salt thereof.