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1. (WO2018158247) IN VITRO SCREENING AND SELECTION OF SPECIFIC DNA APTAMERS AGAINST THE NON-HUMAN SIALIC ACID, N-GLYCOLYL NEURAMINIC ACID (NEU5GC)

Pub. No.:    WO/2018/158247    International Application No.:    PCT/EP2018/054803
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Wed Feb 28 00:59:59 CET 2018
IPC: C07K 16/28
C40B 30/04
G01N 33/532
G01N 33/563
C12N 15/115
Applicants: NATIONAL UNIVERSITY OF IRELAND, GALWAY
Inventors: RAJESH, Sharma
CUNNINGHAM, Stephen
LOKESH, Joshi
Title: IN VITRO SCREENING AND SELECTION OF SPECIFIC DNA APTAMERS AGAINST THE NON-HUMAN SIALIC ACID, N-GLYCOLYL NEURAMINIC ACID (NEU5GC)
Abstract:
The invention relates to methods, assays and compositions for the determination of sialic acid forms. In particular, the invention provides protein and nucleic acid based recognition molecules, for application in the detection, measurement and discrimination of the sialic acid forms N-glycolylneuraminic acid (Neu5Gc) and N-acetylneuraminic acid (Neu5Ac) when presented as either biologically or chemically bound forms or free forms available in suspension.