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1. (WO2018157857) APOPTOTIC SIGNAL REGULATION KINASE INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF
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Pub. No.: WO/2018/157857 International Application No.: PCT/CN2018/077873
Publication Date: 07.09.2018 International Filing Date: 02.03.2018
IPC:
C07D 233/56 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/14 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/4439 (2006.01) ,A61P 1/16 (2006.01) ,A61P 3/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
56
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
江苏豪森药业集团有限公司 JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区 Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
上海翰森生物医药科技有限公司 SHANGHAI HANSOH BIOMEDICAL CO., LTD. [CN/CN]; 中国上海市 张江高科技园区金科路3728号2号楼 Building 2, No.3728 Jinke Road, Zhangjiang Hi-Tech Park Shanghai 201203, CN
Inventors:
高鹏 GAO, Peng; CN
谭松良 TAN, Songliang; CN
修文华 XIU, Wenhua; CN
张福军 ZHANG, Fujun; CN
刘磊 LIU, Lei; CN
包如迪 BAO, Rudi; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO.,LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层 Level 19, Tower E3, The Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710123799.703.03.2017CN
201710713967.818.08.2017CN
201810045023.217.01.2018CN
Title (EN) APOPTOTIC SIGNAL REGULATION KINASE INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF
(FR) INHIBITEUR DE KINASE DE RÉGULATION DU SIGNAL APOPTOTIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 凋亡信号调节激酶抑制剂及其制备方法和应用
Abstract:
(EN) Provided are an amide derivative inhibitor, a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, as well as a use thereof as an ASK1 inhibitor in the treatment of regressive neurological diseases, cardiovascular diseases, inflammation and autoimmune and metabolic diseases; each substituent in general formula (I) is the same as that defined in the description.
(FR) La présente invention concerne un inhibiteur de dérivé d'amide, son procédé de préparation et une application correspondante. La présente invention concerne particulièrement, un composé représenté par la formule générale (I), son procédé de préparation et une composition pharmaceutique contenant le composé, ainsi que leur utilisation en tant qu'inhibiteur d'ASK1 dans le traitement de maladies neurologiques régressives, de maladies cardiovasculaires, d'une inflammation et de maladies auto-immunes et métaboliques ; chaque substituant dans la formule générale (I) est le même que celui défini dans la description.
(ZH) 提供酰胺类衍生物抑制剂、其制备方法和应用。特别地,涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物,及其作为ASK1 抑制剂在治疗神经退休性疾病、心血管疾病、炎症、自身免疫和代谢性疾病的用途,其中通式(I)中的各取代基与说明书中的定义相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)