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1. (WO2018157851) PERIOSTEAL REPAIR SHEET FOR GUIDED BONE REGENERATION, PREPARATION METHOD AND USE

Pub. No.:    WO/2018/157851    International Application No.:    PCT/CN2018/077850
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Sat Mar 03 00:59:59 CET 2018
IPC: A61L 27/48
A61L 27/54
A61L 27/58
A61L 27/56
A61L 27/36
Applicants: BEIJING BIOSIS HEALING BIOLOGICAL TECHNOLOGY CO., LTD
北京博辉瑞进生物科技有限公司
Inventors: ZHAO, Bo
赵博
WANG, Hongquan
王洪权
XIA, Leilei
夏磊磊
ZHAO, Yanrui
赵延瑞
LI, Xuejun
李学军
ZHANG, Jinhui
张晋辉
Title: PERIOSTEAL REPAIR SHEET FOR GUIDED BONE REGENERATION, PREPARATION METHOD AND USE
Abstract:
Disclosed are a periosteal repair sheet for guided bone regeneration, a preparation method and the use. The periosteal repair sheet comprises a high-porosity loose active layer and a low-porosity dense basal layer, collagen, polysaccharide substances and active factors; the loose active layer further comprises active factors for guided bone regeneration; and the periosteal repair sheet, when implanted into the body, can be degraded and absorbed. The preparation method and use thereof are also addressed. The repair sheet, forming a dual-layer composite structure with a loose upper layer and a dense lower layer, is conducive to growth-in of cells, and is capable of improving the repair speed of tissues; the dense layer is an immunogen-removed substrate, and the substrate layer has an isolating effect, effectively protecting the repaired tissues; and a morphogenetic bone protein is added for the repair of periosteal injuries and defects.