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|1. (WO2018157843) 2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF|
|Applicants:||SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
|Title:||2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF|
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO target inhibitor for treating diseases associated with FTO targets, obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer's diseases, breast cancers, small-cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.