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1. (WO2018157843) 2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF

Pub. No.:    WO/2018/157843    International Application No.:    PCT/CN2018/077795
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Fri Mar 02 00:59:59 CET 2018
IPC: C07C 229/58
C07D 231/12
C07D 333/20
C07D 239/26
C07D 413/12
A61K 31/41
A61P 3/00
A61P 9/00
A61P 35/00
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors: YANG, Caiguang
杨财广
HUANG, Yue
黄悦
DONG, Ze
董泽
ZHANG, Tao
张涛
XU, Hongjiao
徐洪蛟
Title: 2-(SUBSTITUTED BENZENE MATRIX) AROMATIC FORMATE FTO INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF
Abstract:
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix) aromatic formate compound represented by the following formula (I), and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, which can be used as an FTO target inhibitor for treating diseases associated with FTO targets, obesity, metabolic syndrome (MS), type 2 diabetes (T2D), Alzheimer's diseases, breast cancers, small-cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.