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1. (WO2018157710) NAV1.9 TARGET POLYPEPTIDE, ANTIBODY AND ANTIBODY FRAGMENT COMBINED WITH SAME, AND RELATED PHARMACEUTICAL COMPOSITION

Pub. No.:    WO/2018/157710    International Application No.:    PCT/CN2018/075597
Publication Date: Sat Sep 08 01:59:59 CEST 2018 International Filing Date: Thu Feb 08 00:59:59 CET 2018
IPC: C07K 16/28
C07K 7/08
A61K 39/395
A61P 25/02
Applicants: WUHAN UNIVERSITY
武汉大学
Inventors: YANG, Daichang
杨代常
Title: NAV1.9 TARGET POLYPEPTIDE, ANTIBODY AND ANTIBODY FRAGMENT COMBINED WITH SAME, AND RELATED PHARMACEUTICAL COMPOSITION
Abstract:
Provided are an antibody or a fragment thereof, which can be specifically bound to an S3-4 ring of a voltage sensor paddle of a domain III of voltage-gated sodium channel Nav1.9 α sub-unit, and is able to inactivate a voltage sensor valve to keep sodium ions from entering nerve cells normally. Also provided is an epitope polypeptide specifically bound to the antibody or the fragment thereof, a pharmaceutical composition comprising the antibody or the fragment thereof, and a use of the antibody or the fragment thereof in preparing a drug for treating diseases related to pains.