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1. (WO2018157465) REPLICATION-DEFECTIVE HUMAN TYPE 14 ADENOVIRUS VECTOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF
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Pub. No.: WO/2018/157465 International Application No.: PCT/CN2017/082901
Publication Date: 07.09.2018 International Filing Date: 03.05.2017
IPC:
C12N 15/861 (2006.01) ,C12N 15/66 (2006.01) ,A61K 39/235 (2006.01) ,A61K 48/00 (2006.01) ,A61P 31/22 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
66
General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
235
Adenoviridae
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
Applicants:
广州恩宝生物医药科技有限公司 GUANGZHOU N BIOMED LTD. [CN/CN]; 中国广东省广州市 高新技术产业开发区瑞发路1号自编1栋二楼201室陈凌 Chen Ling A201#,No. I Ruifa Road, Guangzhou Science Park Guangzhou, Guangdong 510663, CN
Inventors:
陈凌 CHEN, Ling; CN
冯立强 FENG, Liqiang; CN
李楚芳 LI, Chufang; CN
孙西魁 SUN, Xikui; CN
Agent:
广州粤高专利商标代理有限公司 YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY; 中国广东省深圳市 龙岗区龙岗天安数码新城3栋B座4楼F12室杨昕昕 YANG,Xinxin Room 12,Floor 4,Building 3,Longgang Tian'an Digital New City, Longgang District Shenzhen, Guangdong 518100, CN
邓义华 DENG, Yihua; CN
Priority Data:
201710116966.501.03.2017CN
Title (EN) REPLICATION-DEFECTIVE HUMAN TYPE 14 ADENOVIRUS VECTOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF
(FR) VECTEUR D'ADÉNOVIRUS DE TYPE 14 HUMAIN À RÉPLICATION DÉFECTUEUSE, PROCÉDÉ DE PRÉPARATION ET APPLICATIONS ASSOCIÉES
(ZH) 一种复制缺陷型人14型腺病毒载体及其制备方法和应用
Abstract:
(EN) Provided in the present invention are a replication-defective human type 14 adenovirus vector and a preparation method therefor. The method is as follows: plasmidizing Ad14 genome, knocking off genes E3 and E1, and substituting open reading frames 2, 3, 4, 6, and 6/7 of gene E4 with corresponding reading frames of Ad5 genome. The replication-defective type 14 adenovirus vector of the present invention is potentially applicable in the research and development of a vaccine and a medicament for use in combating human type 14 adenovirus infection, applicable as a gene vector in the research and development of other pathogen vaccines, and applicable in a report and tracing system for biological research.
(FR) La présente invention concerne un vecteur d'adénovirus de type 14 humain à réplication défectueuse et son procédé de préparation. Le procédé est le suivant : plasmidisation du génome de l'Ad14, knock-off des gènes E3 et E1, et substitution des cadres de lecture ouverts 2, 3, 4, 6, et 6/7 du gène E4 avec des cadres de lecture correspondants du génome de l'Ad5. Le vecteur d'adénovirus de type 14 à réplication défectueuse de la présente invention peut potentiellement être appliqué dans la recherche et le développement d'un vaccin et d'un médicament destinés à être utilisés dans la lutte contre une infection par l'adénovirus de type 14 humain, appliqué en tant que vecteur de gène dans la recherche et le développement d'autres vaccins pathogènes, et appliqué dans un système de rapport et de suivi pour la recherche biologique.
(ZH) 本发明提供了一种复制缺陷型人14型腺病毒载体及其制备方法,所述方法如下:将Ad14基因组质粒化,敲除E3和E1基因,进而将E4基因开放阅读框2、3、4、6、6/7改换为Ad5基因组的相应阅读框。本发明所述复制缺陷型14型腺病毒载体可潜在应用于抗人14型腺病毒感染的疫苗和药物的研发,作为基因载体应用于其他病原体疫苗的研发,以及应用于生物学研究的报告示踪系统等。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)