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1. WO2018154048 - METHOD FOR THE PREPARATION OF (3E,7E)-HOMOFARNESIC ACID OR (3E,7E)-HOMOFARNESIC ACID ESTER

Publication Number WO/2018/154048
Publication Date 30.08.2018
International Application No. PCT/EP2018/054502
International Filing Date 23.02.2018
Chapter 2 Demand Filed 21.12.2018
IPC
C12P 7/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
62Carboxylic acid esters
C12P 7/40 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group
C12P 17/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
04containing a five-membered hetero ring, e.g. griseofulvin
C07C 69/533 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
533Monocarboxylic acid esters having only one carbon-to-carbon double bond
C07C 57/03 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
57Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
02with only carbon-to-carbon double bonds as unsaturation
03Monocarboxylic acids
CPC
C07D 307/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
92Naphthofurans; Hydrogenated naphthofurans
C12P 17/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
04containing a five-membered hetero ring, e.g. griseofulvin ; , vitamin C
C12P 41/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
003by ester formation, lactone formation or the inverse reactions
005by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
C12P 7/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group ; including Peroxycarboxylic acids
C12P 7/62
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
62Carboxylic acid esters
C12Y 301/01003
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
301Hydrolases acting on ester bonds (3.1)
01Carboxylic ester hydrolases (3.1.1)
01003Triacylglycerol lipase (3.1.1.3)
Applicants
  • BASF SE [DE]/[DE]
Inventors
  • SIEGEL, Wolfgang
  • WEINGARTEN, Melanie
  • BREUER, Michael
  • SCHELWIES, Mathias
Agents
  • REITSTÖTTER KINZEBACH
Priority Data
17157974.124.02.2017EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR THE PREPARATION OF (3E,7E)-HOMOFARNESIC ACID OR (3E,7E)-HOMOFARNESIC ACID ESTER
(FR) PROCÉDÉ DE PRÉPARATION D'ACIDE (3E,7E)-HOMOFARNÉSIQUE OU D'ESTER D'ACIDE (3E,7E)-HOMOFARNÉSIQUE
Abstract
(EN)
The invention provides an improved method of isolating the 3-(E)-isomer of an unsaturated carboxylic acid from a mixture of corresponding (E/Z)isomers. More particularly, the present invention relates to an improved method for the biocatalytic preparation of (3E,7E)-homofarnesylic acid; as well as a novel biocatalytic method for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations having an increased content of (3E,7E)-homofarnesol. The present invention also relates to methods of preparing(-)-ambroxby applying (3E,7E)- homofarnesylic acid or (3E,7E)-homofarnesol as obtained according to the invention as starting material.
(FR)
L'invention concerne un procédé amélioré d'isolement de l'isomère 3-(E) d'un acide carboxylique insaturé à partir d'un mélange d'isomères (E/Z) correspondants. Plus particulièrement, la présente invention concerne un procédé amélioré de préparation biocatalytique d'acide (3E,7E)-homofarnésylique ; ainsi qu'un nouveau procédé biocatalytique pour la préparation améliorée d'homofarnésol, en particulier de (3E,7E)-homofarnésol et de préparations d'homofarnésol ayant une teneur accrue en (3E,7E)-homofarnésol. La présente invention concerne également des procédés de préparation de (-)-ambrox en utilisant de l'acide (3E,7E)-homofarnésylique ou du (3E,7E)-homofarnésol obtenu selon l'invention en tant que matière de départ.
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