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1. WO2018152120 - METHODS OF ENGINEERING HUMAN INDUCED PLURIPOTENT STEM CELLS TO PRODUCE LIVER TISSUE

Publication Number WO/2018/152120
Publication Date 23.08.2018
International Application No. PCT/US2018/018032
International Filing Date 13.02.2018
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
074
Adult stem cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
37
Digestive system
407
Liver
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C12N 5/074 (2010.01)
A61K 35/407 (2015.01)
A01K 67/027 (2006.01)
CPC
A01K 2207/12
A01K 2217/075
A01K 2227/10
A01K 2227/105
A01K 2267/025
A01K 67/027
Applicants
  • UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US/US]; 1st Floor Gardner Steel Conference Center 130 Thackeray Avenue Pittsburgh, PA 15260, US
Inventors
  • SOTO-GUTIERREZ, Alejandro; US
  • MASHIMO, Tomoji; JP
  • COLLIN DE I'HORTET, Alexandra, Sylvie; US
  • ALVAREZ, Eduardo, Cervantes; US
  • LEPE, Jorge, Guzman; US
  • HANDA, Kan; US
  • TAKEISHI, Kazuki; US
  • WANG, Yang; US
  • POPOVIC, Branimir; US
Agents
  • SIEGEL, Susan, Alpert; US
Priority Data
62/459,00314.02.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF ENGINEERING HUMAN INDUCED PLURIPOTENT STEM CELLS TO PRODUCE LIVER TISSUE
(FR) PROCÉDÉS D'INGÉNIERIE DE CELLULES SOUCHES PLURIPOTENTES INDUITES HUMAINES POUR PRODUIRE UN TISSU HÉPATIQUE
Abstract
(EN)
Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.
(FR)
L'invention concerne des procédés de production d'hépatocytes humains à partir de cellules souches pluripotentes induites humaines. L'invention concerne également des rats transgéniques pour l'expansion d'hépatocytes humains, tels que ceux produits à l'aide des procédés décrits dans la présente invention.
Also published as
JP2019543338
Latest bibliographic data on file with the International Bureau