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1. WO2018148447 - ANTIBODY HEAVY CHAIN VARIABLE DOMAINS TARGETING THE NKG2D RECEPTOR

Publication Number WO/2018/148447
Publication Date 16.08.2018
International Application No. PCT/US2018/017474
International Filing Date 08.02.2018
IPC
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
C07K 16/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
Applicants
  • DRAGONFLY THERAPEUTICS, INC. [US]/[US]
Inventors
  • CHANG, Gregory, P.
  • CHEUNG, Ann, F.
  • HANEY, William
  • LUNDE, Bradley, M.
  • PRINZ, Bianka
Agents
  • ASHRAF, Shovon
  • BUCHMAN, Joshua, J.
  • BRODOWSKI, Michael
  • DAVENPORT, Andrew, M.
  • ARGENTIERI, Steven, R.
Priority Data
62/456,54408.02.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODY HEAVY CHAIN VARIABLE DOMAINS TARGETING THE NKG2D RECEPTOR
(FR) DOMAINES VARIABLES DE CHAÎNES LOURDES D'ANTICORPS CIBLANT LE RÉCEPTEUR NKG2D
Abstract
(EN)
Antibody heavy chain variable domains that can be paired with any of a variety of antibody light chain variable domains to form an antigen binding site targeting the NKG2D receptor on natural killer cells are described. Also described are antibodies and antigen- binding sites that compete for binding to NKG2D. Related pharmaceutical compositions and therapeutic methods, including for the treatment of cancer, are also described.
(FR)
Cette invention concerne des domaines variables de chaînes lourdes d'anticorps qui peuvent être appariés à divers domaines variables de chaînes légères d'anticorps pour former un site de liaison à l'antigène ciblant le récepteur NKG2D sur des cellules tueuses naturelles. L'invention concerne également des anticorps et des sites de liaison à l'antigène qui sont en compétition pour la liaison à NKG2D. Des compositions pharmaceutiques et des méthodes thérapeutiques associées, notamment pour le traitement du cancer, sont en outre décrites.
Also published as
EP2018751673
Latest bibliographic data on file with the International Bureau