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1. WO2018147624 - INSULIN A-CHAIN DERIVED PEPTIDE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC WOUNDS, CONTAINING SAME

Publication Number WO/2018/147624
Publication Date 16.08.2018
International Application No. PCT/KR2018/001620
International Filing Date 07.02.2018
IPC
C07K 5/083 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/103 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
103the side chain of the first amino acid being acyclic, e.g. Gly, Ala
A61K 38/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
A61K 38/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
A61K 38/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07Tetrapeptides
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 5/081
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
081the side chain containing O or S as heteroatoms, e.g. Cys, Ser
C07K 5/0812
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0812and aromatic or cycloaliphatic
Applicants
  • 강원대학교산학협력단 KNU-INDUSTRY COOPERATION FOUNDATION [KR]/[KR]
  • (주) 수파드엘릭사 SUPADELIXIR INC. [KR]/[KR]
Inventors
  • 한장희 HAHN, Jang-Hee
  • 김창겸 KIM, Chang-Gyum
Agents
  • 오국진 OH, Kook-Jin
Priority Data
10-2017-001811609.02.2017KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) INSULIN A-CHAIN DERIVED PEPTIDE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC WOUNDS, CONTAINING SAME
(FR) FRAGMENT PEPTIDIQUE DÉRIVÉ DE LA CHAÎNE A DE L'INSULINE ET COMPOSITION PHARMACEUTIQUE CONTENANT CELUI-CI DESTINÉE À PRÉVENIR OU TRAITER LE DIABÈTE OU LES PLAIES DIABÉTIQUES
(KO) 인슐린의 A 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물
Abstract
(EN)
Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the present invention induces endocytosis through insulin receptors, has activities of increasing glucose uptake of cells by translocating glucose transporters onto a cell membrane, and of increasing cell migration and proliferation. Therefore, the peptide of the present invention can be usefully applicable in the prevention or treatment of diabetes or diabetic wounds.
(FR)
La présente invention concerne un fragment peptidique dérivé de la chaîne A de l'insuline et une composition pharmaceutique contenant celui-ci en tant que principe actif destinée à prévenir ou traiter le diabète ou les plaies diabétiques. Le peptide de la présente invention induit une endocytose par l'intermédiaire des récepteurs de l'insuline, présente des activités d'augmentation de l'absorption du glucose par les cellules en effectuant la translocation des transporteurs de glucose sur une membrane cellulaire, et d'augmentation de la migration et de la prolifération cellulaires. Par conséquent, le peptide de la présente invention peut être utilement appliqué dans la prévention ou le traitement du diabète ou des plaies diabétiques.
(KO)
본 발명은 인슐린의 A 사슬로부터 유래된 펩타이드 단편 및 이를 유효성분으로 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물을 제공한다. 본 발명의 펩타이드는 인슐린 수용체를 통하여 엔도사이토시스를 유도하고, 포도당 수송체를 세포막에 전위함으로써 세포의 포도당 유입을 증가시키는 활성을 가지며, 세포의 이동 및 증식이 증가시키는 활성을 갖는다. 따라서, 본 발명의 펩타이드는 당뇨병 및 당뇨병성 창상의 예방 또는 치료에 유용하게 적용될 수 있다.
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