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1. WO2018146698 - IMPROVED METHOD FOR THE PREPARATION OF SULFOBUTYLETHER BETA CYCLODEXTRIN SODIUM

Publication Number WO/2018/146698
Publication Date 16.08.2018
International Application No. PCT/IN2018/050063
International Filing Date 07.02.2018
IPC
A61K 31/724 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
C08B 37/16 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
16Cyclodextrin; Derivatives thereof
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
C08L 5/16 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5Compositions of polysaccharides or of their derivatives not provided for in group C08L1/ or C08L3/142
16Cyclodextrin; Derivatives thereof
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C08B 37/0012
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
0009alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
C08L 5/16
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
16Cyclodextrin; Derivatives thereof
Applicants
  • BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. [IN]/[IN]
Inventors
  • PULLAGURLA, Manik Reddy
  • PITTA, Bhaskar Reddy
  • NAMANA, Suresh Babu
  • NAGARAPU, Radha
  • RANGISETTY, Jagadeesh Babu
Agents
  • HASAN, Afzal
  • HASAN, Vatsala Singh
Priority Data
20174100449307.02.2017IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED METHOD FOR THE PREPARATION OF SULFOBUTYLETHER BETA CYCLODEXTRIN SODIUM
(FR) PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE SULFOBUTYLÉTHER BÊTA-CYCLODEXTRINE SODIQUE
Abstract
(EN)
The present invention relates to an improved method for the synthesis of sulfobutylether beta cyclodextrin sodium and to provide an amorphous form of sulfobutylether beta cyclodextrin sodium having a 1,4-butane sultone content less than 0.5 ppm. The present invention further provides sulfobutylether beta cyclodextrin sodium containing less than 35 IU/g of Bacterial endotoxins.
(FR)
L'invention concerne un procédé amélioré de synthèse de sulfobutyléther bêta-cyclodextrine sodique. L'invention concerne également une forme amorphe de sulfobutyléther bêta-cyclodextrine sodique ayant une teneur en 1,4-butane-sultone inférieure à 0,5 ppm. L'invention concerne également du sulfobutyléther bêta-cyclodextrine sodique contenant moins de 35 UI/g d'endotoxines bactériennes.
Also published as
Latest bibliographic data on file with the International Bureau