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1. WO2018146562 - SPARSITY-BASED SUPER-RESOLUTION CORRELATION MICROSCOPY

Publication Number WO/2018/146562
Publication Date 16.08.2018
International Application No. PCT/IB2018/050253
International Filing Date 16.01.2018
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G06T 5/00 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
5Image enhancement or restoration
CPC
G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 21/6408
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6408with measurement of decay time, time resolved fluorescence
G01N 21/6458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6456Spatial resolved fluorescence measurements; Imaging
6458Fluorescence microscopy
G02B 21/0076
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0052Optical details of the image generation
0076arrangements using fluorescence or luminescence
G02B 27/58
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
27Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
58Optics for apodization or superresolution; Optical synthetic aperture systems
G06T 2207/10016
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
2207Indexing scheme for image analysis or image enhancement
10Image acquisition modality
10016Video; Image sequence
Applicants
  • TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. [IL]/[IL]
Inventors
  • ELDAR, Yonina
  • SEGEV, Mordechai
  • SOLOMON, Oren
  • MUTZAFI, Maor
Agents
  • D. KLIGLER I. P. SERVICES LTD.
Priority Data
62/456,71409.02.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SPARSITY-BASED SUPER-RESOLUTION CORRELATION MICROSCOPY
(FR) MICROSCOPIE DE CORRÉLATION À SUPER-RÉSOLUTION SUR LA BASE DE LA RARETÉ
Abstract
(EN)
An imaging apparatus (20) includes an interface (50) and a processor (30). The interface is configured to receive a sequence of images of an object (38) acquired at respective acquisition times, the object is labeled with fluorescent emitters. The images depict intensity fluctuations of emitters on an acquisition grid, and the intensity fluctuations being uncorrelated among the emitters and during an overall time over which the images in the sequence are acquired. The a processor is configured to calculate a temporal correlation function of the intensity fluctuations over the sequence of images, and to estimate locations of the emitters on a super-resolution grid having a higher resolution than the acquisition grid, by applying to the temporal correlation function a recovery process in which the locations on the super-resolution grid are assumed to be sparse or compressible in a predefined domain. The recovery process includes a sparse-recovery process or a regularized process.
(FR)
L’invention concerne un appareil imageur (20) qui inclut une interface (50) et un processeur (30). L’interface est configurée pour recevoir une séquence d’images d’un objet (38) acquises à des instants d’acquisition respectifs, l’objet est marqué par des émetteurs fluorescents. Les images décrivent des fluctuations d’intensité d’émetteurs sur une grille d’acquisition, et les fluctuations d’intensité qui ne sont pas corrélées parmi les émetteurs et pendant un temps global durant lequel les images dans la séquence sont acquises. Le processeur est configuré pour calculer une fonction de corrélation temporelle des fluctuations d’intensité sur la séquence d’images, et pour estimer des positions des émetteurs sur une grille à super-résolution dont la résolution est supérieure à celle de la grille d’acquisition, en appliquant à la fonction de corrélation temporelle un processus de récupération dans lequel les positions sur la grille de super-résolution sont supposées rares ou compressibles dans un domaine prédéfini. Le processus de récupération inclut un processus de récupération de rareté ou un processus régularisé.
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