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1. (WO2018146562) SPARSITY-BASED SUPER-RESOLUTION CORRELATION MICROSCOPY
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Pub. No.: WO/2018/146562 International Application No.: PCT/IB2018/050253
Publication Date: 16.08.2018 International Filing Date: 16.01.2018
IPC:
G01N 21/64 (2006.01) ,G06T 5/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21
Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible, or ultra-violet light
62
Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63
optically excited
64
Fluorescence; Phosphorescence
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
T
IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
5
Image enhancement or restoration, e.g. from bit-mapped to bit-mapped creating a similar image
Applicants:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. [IL/IL]; Technion Israel Institute of Technology, Senate Building 32000 Haifa, IL
Inventors:
ELDAR, Yonina; IL
SEGEV, Mordechai; IL
SOLOMON, Oren; IL
MUTZAFI, Maor; IL
Agent:
D. KLIGLER I. P. SERVICES LTD.; P. O. Box 57651 61576 Tel Aviv, IL
Priority Data:
62/456,71409.02.2017US
Title (EN) SPARSITY-BASED SUPER-RESOLUTION CORRELATION MICROSCOPY
(FR) MICROSCOPIE DE CORRÉLATION À SUPER-RÉSOLUTION SUR LA BASE DE LA RARETÉ
Abstract:
(EN) An imaging apparatus (20) includes an interface (50) and a processor (30). The interface is configured to receive a sequence of images of an object (38) acquired at respective acquisition times, the object is labeled with fluorescent emitters. The images depict intensity fluctuations of emitters on an acquisition grid, and the intensity fluctuations being uncorrelated among the emitters and during an overall time over which the images in the sequence are acquired. The a processor is configured to calculate a temporal correlation function of the intensity fluctuations over the sequence of images, and to estimate locations of the emitters on a super-resolution grid having a higher resolution than the acquisition grid, by applying to the temporal correlation function a recovery process in which the locations on the super-resolution grid are assumed to be sparse or compressible in a predefined domain. The recovery process includes a sparse-recovery process or a regularized process.
(FR) L’invention concerne un appareil imageur (20) qui inclut une interface (50) et un processeur (30). L’interface est configurée pour recevoir une séquence d’images d’un objet (38) acquises à des instants d’acquisition respectifs, l’objet est marqué par des émetteurs fluorescents. Les images décrivent des fluctuations d’intensité d’émetteurs sur une grille d’acquisition, et les fluctuations d’intensité qui ne sont pas corrélées parmi les émetteurs et pendant un temps global durant lequel les images dans la séquence sont acquises. Le processeur est configuré pour calculer une fonction de corrélation temporelle des fluctuations d’intensité sur la séquence d’images, et pour estimer des positions des émetteurs sur une grille à super-résolution dont la résolution est supérieure à celle de la grille d’acquisition, en appliquant à la fonction de corrélation temporelle un processus de récupération dans lequel les positions sur la grille de super-résolution sont supposées rares ou compressibles dans un domaine prédéfini. Le processus de récupération inclut un processus de récupération de rareté ou un processus régularisé.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)