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1. (WO2018146534) METHODS AND BIOSENSORS FOR TUMOR DETECTION

Pub. No.:    WO/2018/146534    International Application No.:    PCT/IB2017/058396
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Tue Dec 26 00:59:59 CET 2017
IPC: G01N 33/50
G01N 27/26
Applicants: AMOUZADEH TABRIZI, Mahmoud
Inventors: AMOUZADEH TABRIZI, Mahmoud
SHAMSIPUR, Mojtaba
SABER, Reza
SARKAR, Saeed
Title: METHODS AND BIOSENSORS FOR TUMOR DETECTION
Abstract:
Disclosed herein is a method for tumor marker detection. The method includes preparing a biosensor, forming a reference solution by adding the biosensor to a buffer solution, measuring a first fluorescence intensity of the reference solution, forming a mixture by adding a suspicious biological solution to the reference solution, measuring a second fluorescence intensity of the mixture, and detecting a presence of a tumor marker responsive to a difference between the first fluorescence intensity and the second fluorescence intensity. The biosensor preparation includes forming a functionalized nanomotor by functionalizing a nanomotor with an aptamer, forming a blocked functionalized nanomotor by blocking gaps between functionalized parts of the functionalized nanomotor with a blocking agent, and attaching a fluorescence probe to the blocked functionalized nanomotor.