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1. (WO2018146529) A PROCESS FOR PREPARATION OF1-[2-(DIMETHYLAMINO)-1-(4-HYDROXYPHENYL) ETHYL]-CYCLOHEXANOL AND SALTS THEREOF
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Pub. No.: WO/2018/146529 International Application No.: PCT/IB2017/051843
Publication Date: 16.08.2018 International Filing Date: 31.03.2017
IPC:
C07C 213/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
213
Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
Applicants:
R L FINECHEM PRIVATE LIMITED [IN/IN]; No. 15, KHB Industrial Area, Yelahanka, Bengaluru-560064, Karnataka, India BENGALURU 560064, IN
Inventors:
A RAMAKRISHNA, Ramesha; IN
S MARAVANAHALLI, Siddegowda; IN
MAHIL, Santosh; IN
Agent:
KRISHNAMURTHY, Rama; IN
P SHENOI, Namratha; IN
Priority Data:
20174100470209.02.2017IN
Title (EN) A PROCESS FOR PREPARATION OF1-[2-(DIMETHYLAMINO)-1-(4-HYDROXYPHENYL) ETHYL]-CYCLOHEXANOL AND SALTS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE 1-[2-(DIMÉTHYLAMINO)-1-(4-HYDROXYPHÉNYL) ÉTHYL]-CYCLOHEXANOL ET DE SES SELS
Abstract:
(EN) The present invention relates to a high yield process of preparation of, [1-[2-(Dimethylamino)-1- (4-hydroxyphenyl)ethyl]-cyclohexanol]through potassium hydroxide mediated demethylation of [1-[2-(Dimethyl amino-1-(4-methoxyphenyl) ethyl cyclohexanol]in monoethylene glycol under phase transfer conditions. The invention also relates to preparation of salt of [1-[2- (Dimethylamino)-1-(4-hydroxyphenyl)ethyl]-cyclohexanol].
(FR) La présente invention concerne un procédé à haut rendement de préparation de [1-[2-(diméthylamino)-1-(4-hydroxyphényl))éthyl]-cyclohexanol] par déméthylation induite par l'hydroxyde de potassium de [1-[2-(diméthyl amino-1-(4-méthoxyphényl) éthyl cyclohexanol] dans du monoéthylène glycol dans des conditions de transfert de phase. L'invention concerne également la préparation de sel de [1-[2-(diméthylamino)-1-(4-hydroxyphényl)éthyl]-cyclohexanol].
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)