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1. (WO2018146485) TRPC ION CHANNEL INHIBITORS FOR USE IN THERAPY

Pub. No.:    WO/2018/146485    International Application No.:    PCT/GB2018/050369
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Sat Feb 10 00:59:59 CET 2018
IPC: A61K 31/522
A61K 31/4184
A61K 31/713
C07D 235/14
A61P 1/16
A61P 3/04
A61P 3/08
A61P 3/10
G01N 33/68
Applicants: UNIVERSITY OF LEEDS
Inventors: BEECH, David John
FOSTER, Richard James
CHEUNG, Sin Ying
RODE, Baptiste Michel
Title: TRPC ION CHANNEL INHIBITORS FOR USE IN THERAPY
Abstract:
Described herein are inhibitors of Transient Receptor Potential Canonical (TRPC) ion channels, comprising TRPC4 protein and/or TRPC5 protein, for use in combating obesity and other medical conditions, including insulin resistance associated with Type II diabetes or development of Type II diabetes (pre-diabetes), metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Also disclosed is the use of the inhibitors for cosmetic purposes, such as cosmetic weight loss.