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1. (WO2018146321) ANTIBODIES RECOGNIZING GENETIC VARIANTS

Pub. No.:    WO/2018/146321    International Application No.:    PCT/EP2018/053474
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Wed Feb 14 00:59:59 CET 2018
IPC: A61K 39/395
C07K 16/26
G01N 33/68
Applicants: ROCHE DIAGNOSTICS GMBH
F. HOFFMANN-LA ROCHE AG
ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventors: HALLERMAYER, Klaus
SOUKUPOVA, Monika
PORZIG, Christina
KURTKAYA, Ulrike
VON PROFF, Leopold
FIESEL, Sonja
HERRMANN, Marion
KERN, Stefanie
Title: ANTIBODIES RECOGNIZING GENETIC VARIANTS
Abstract:
The present invention relates to an antibody that specifically binds a mutated NT-proBNP comprising i) a mutation substituting arginine at position 46 with histidine or ii) a mutation substituting glutamic acid at position 43 with aspartic acid. Moreover, the present invention relates to a mutated NT-proBNP or fragment thereof. Further, envisaged by the present invention are kits comprising the antibody of the present invention, or the mutated NT-proBNP of the present invention. The present invention also concerns a method for diagnosing heart failure.