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1. (WO2018146264) PURIFICATION OF PLEUROMUTILIN
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Pub. No.: WO/2018/146264 International Application No.: PCT/EP2018/053314
Publication Date: 16.08.2018 International Filing Date: 09.02.2018
Chapter 2 Demand Filed: 15.11.2018
IPC:
C07C 67/52 (2006.01) ,C07C 69/675 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
67
Preparation of carboxylic acid esters
48
Separation; Purification; Stabilisation; Use of additives
52
by change in the physical state, e.g. crystallisation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
69
Esters of carboxylic acids; Esters of carbonic or haloformic acids
66
Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67
of saturated acids
675
of saturated hydroxy-carboxylic acids
Applicants:
NABRIVA THERAPEUTICS GMBH [AT/AT]; Leberstraße 20 1110 Wien, AT
Inventors:
HEILMAYER, Werner; AT
SPENCE, Lee; AT
HINSMANN, Peter; AT
Agent:
SCHWARZ & PARTNER PATENTANWÄLTE OG; Wipplingerstrasse 30 1010 Wien, AT
NEMEC, Harald; AT
Priority Data:
17155542.810.02.2017EP
Title (EN) PURIFICATION OF PLEUROMUTILIN
(FR) PURIFICATION DE PLEUROMUTILINE
Abstract:
(EN) The present invention relates to purification methods of pleuromutilin (I) by means of crystallisation and/or recrystallisation. The process according to the present invention is carried out in the presence of i-propylacetate.
(FR) La présente invention concerne des procédés de purification de pleuromutiline (I) par cristallisation et/ou recristallisation. Le procédé selon la présente invention est mis en œuvre en présence d'i-propylacétate.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)