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1. WO2018146188 - PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES

Publication Number WO/2018/146188
Publication Date 16.08.2018
International Application No. PCT/EP2018/053162
International Filing Date 08.02.2018
Chapter 2 Demand Filed 28.11.2018
IPC
A61K 47/68 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/5517
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
551having two nitrogen atoms, e.g. dilazep
55131,4-Benzodiazepines, e.g. diazepam ; or clozapine
5517condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/6803
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
A61K 47/6849
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6849the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
A61K 47/6889
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • MEDIMMUNE LIMITED [GB]/[GB]
Inventors
  • VAN BERKEL, Patricius Hendrikus Cornelis
Agents
  • WATSON, Robert
  • ADDISS, John
  • ANDREWS, Robert
  • BAILEY, Sam
  • BRASNETT, Adrian
  • BREARLEY, Sarah
  • BURNS, Alexander
  • CARLISLE, Julie
  • CARTER, Stephen
  • CASLEY, Christopher
  • CLEGG, Richard
  • CRIPPS, Joanna
  • DALE, Elizabeth
  • DENISON, Christopher
  • DUNNE, Paul
  • FORREST, Graham
  • FURNIVAL, Tom
  • GILL, Stephen
  • GRAHAM, Emma
  • GREEN, Katherine
  • GREGORY, Adam
  • HARRISON, Susan
  • HAYES, Emily
  • HODSDON, Stephen
  • JOHNSON, Richard
  • JONES, Rachel
  • KEIRSTEAD, Tanis
  • KIDDLE, Simon
  • KREMER, Simon
  • LEACH, James
  • LENTHALL, Joseph
  • LYONS, June
  • MACIVER, Eleanor
  • MCGUINN, Callum
  • MOELLER, Christoph
  • MOORE, Graeme
  • NAYLOR, Matthew
  • OXLEY, Rachel
  • PARRY, Simon
  • SALISBURY, Frances
  • SMITH, Matthew
  • STONER, Patrick
  • SUTCLIFFE, Nicholas
  • THORNTON, Dan
  • TOLLERVEY, Rebecca
  • WALTON, Seán
  • WARD, Eliot
  • WEBSTER, Jeremy
  • WESCOTT, Rhiannon
  • WILLS, Jonathan
  • WYTENBURG, Wilhelmus
Priority Data
1702031.408.02.2017GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
(FR) CONJUGUÉS ANTICORPS-PYRROLOBENZODIAZÉPINE
Abstract
(EN)
A conjugate of formula (I): Ab − (DL)p wherein: Ab is an antibody, or an active fragment of an antibody; DL is (II).
(FR)
L'invention concerne un conjugué de formule (I) : Ab − (DL)p dans laquelle : Ab est un anticorps, ou un fragment actif d'un anticorps; DL est (II).
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