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1. (WO2018146155) TIM-3 FOR ASSESSING THE SEVERITY OF CANCER

Pub. No.:    WO/2018/146155    International Application No.:    PCT/EP2018/053086
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Thu Feb 08 00:59:59 CET 2018
IPC: C12Q 1/68
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
SORBONNE UNIVERSITE
UNIVERSITÉ PARIS DIDEROT - PARIS 7
UNIVERSITE PARIS DESCARTES
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Inventors: GALON, Jérôme
MLECNIK, Bernhard
BINDEA, Gabriela
Title: TIM-3 FOR ASSESSING THE SEVERITY OF CANCER
Abstract:
The present invention relates to methods for assessing the severity of cancer by measuring the expression level of TIM-3 in a tumour sample. The present inventors have determined that the expression of TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) can be correlated with the prognosis and with the responsiveness to treatment of patients suffering from solid cancer. They have particularly demonstrated that the specific ratio of the expression level of TIM-3 to the expression level of a biomarker of the adaptive immune response within the tumour is extremely predictive of patients' survival. Thus, the present invention relates to methods for determining the prognosis patients suffering from a solid cancer by determining the ratio of the expression level of TIM-3 to the expression level of a biomarker of the adaptive immune response in a tumour tissue sample obtained from said patient. Typically, these expression levels are determined by immunohistochemistry.