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1. (WO2018145649) CONSTRUCTION OF CHIMERIC ANTIGEN RECEPTOR TARGETING CD20 ANTIGEN AND ACTIVITY IDENTIFICATION OF ENGINEERED T CELLS THEREOF
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Pub. No.: WO/2018/145649 International Application No.: PCT/CN2018/075867
Publication Date: 16.08.2018 International Filing Date: 08.02.2018
IPC:
C07K 19/00 (2006.01) ,C12N 15/62 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/867 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
西比曼生物科技(上海)有限公司 CELLULAR BIOMEDICINE GROUP (SHANGHAI) LTD. [CN/CN]; 中国上海市 徐汇区桂平路333号1号楼5楼 Level 5, Building 1, 333 Guiping Road, Xuhui District Shanghai 200233, CN
西比曼生物科技(无锡)有限公司 CELLULAR BIOMEDICINE GROUP (WUXI) LTD. [CN/CN]; 中国江苏省无锡市 惠山区惠山大道1619号2号楼301室 Building 2, Suite 301, 1619 Huishan Road, Huishan District Wuxi, Jiangsu 214174, CN
Inventors:
姚意弘 YAO, Yihong; CN
黄家琪 HUANG, Jiaqi; CN
朱恃贵 ZHU, Shigui; CN
朱蔚 ZHU, Wei; CN
姚昕 YAO, Xin; CN
李志远 LI, Zhiyuan; CN
张丽 ZHANG, Li; CN
朱琳 ZHU, Lin; CN
马安云 MA, Anyun; CN
魏雨恬 WEI, Yutian; CN
李延峰 LI, Yanfeng; CN
王庆霞 WANG, Qingxia; CN
何佳平 HE, Jiaping; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room No.106, Building No.1, Universal High-Tech Plaza 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710069569.708.02.2017CN
Title (EN) CONSTRUCTION OF CHIMERIC ANTIGEN RECEPTOR TARGETING CD20 ANTIGEN AND ACTIVITY IDENTIFICATION OF ENGINEERED T CELLS THEREOF
(FR) CONSTRUCTION D'UN RÉCEPTEUR D'ANTIGÈNE CHIMÈRE CIBLANT UN ANTIGÈNE CD20 ET IDENTIFICATION D'ACTIVITÉ DE LYMPHOCYTES T GÉNÉTIQUEMENT MODIFIÉES DE CELUI-CI
(ZH) 一种靶向CD20抗原嵌合抗原受体的构建及其工程化T细胞的活性鉴定
Abstract:
(EN) Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO. 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO. 11 or 13 or 35, and is capable of killing tumor cells.
(FR) L'invention concerne un récepteur d'antigène chimère ciblant un antigène CD20 et son procédé de préparation. Le domaine de liaison à l'antigène extracellulaire du récepteur d'antigène chimère comprend une région variable de chaîne lourde d'anticorps représentée dans SEQ ID NO. 7 ou 9 ou 33 et une région variable de chaîne légère d'anticorps représentée dans SEQ ID NO. 11 ou 13 ou 35, et est capable d'éliminer des cellules tumorales.
(ZH) 提供了一种靶向CD20抗原嵌合抗原受体及其制备方法,所述嵌合抗原受体的细胞外抗原结合结构域包括SEQ ID NO.7或9或33所示的抗体重链可变区和SEQ ID NO.11或13或35所示的抗体轻链可变区,具有杀伤肿瘤细胞的能力。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)