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1. (WO2018145621) QUINOLINE COMPOUND, PREPARATION METHOD AND MEDICAL USE THEREFOR
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Pub. No.: WO/2018/145621 International Application No.: PCT/CN2018/075392
Publication Date: 16.08.2018 International Filing Date: 06.02.2018
IPC:
C07D 215/02 (2006.01) ,C07D 215/16 (2006.01) ,C07D 401/12 (2006.01) ,A61K 31/47 (2006.01) ,A61K 31/4709 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
恩瑞生物医药科技(上海)有限公司 ANCUREALL PHARMACEUTICAL (SHANGHAI) CO., LTD. [CN/CN]; 中国上海市 自由贸易试验区法拉第路249号7幢第二层西楼面 2nd Floor, West-Wing, Building 7 249 Faladi Rd, Shanghai Pilot Free Trade Zone Shanghai 201210, CN
Inventors:
司聚同 SI, Jutong; CN
姜美锋 JIANG, Meifeng; CN
李加艳 LI, Jiayan; CN
曾含 ZENG, Han; CN
杨华斌 YANG, Huabin; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层1901 Level 19, Tower E3, The Towers, Oriental Plaza No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710067692.507.02.2017CN
Title (EN) QUINOLINE COMPOUND, PREPARATION METHOD AND MEDICAL USE THEREFOR
(FR) COMPOSÉ DE QUINOLÉINE, PROCÉDÉ DE PRÉPARATION ET UTILISATION MÉDICALE ASSOCIÉS
(ZH) 喹啉类化合物、其制备方法及其医药用途
Abstract:
(EN) The present invention relates to a quinoline compound, as well as a preparation method and medical use therefor. Specifically, the present invention relates to a novel quinoline compound represented by the general formula (I) and a method for preparing the same, as well as a use therefor as an inhibitor for a plurality of protein kinases, and a use in the prevention and/or treatment of cancer in particular; the definition of each group in the general formula (I) is the same as the definition in the description.
(FR) La présente invention concerne un composé de quinoléine, son procédé de préparation et une utilisation médicale associée. La présente invention concerne particulièrement, un nouveau composé de quinoléine représenté par la formule générale (I) et son procédé de préparation, ainsi qu'une utilisation de celui-ci en tant qu'inhibiteur pour une pluralité de protéines kinases, et une utilisation dans la prévention et/ou le traitement du cancer, en particulier ; la définition de chaque groupe dans la formule générale (I) est la même que celle donnée dans la description.
(ZH) 本发明涉及一种喹啉类化合物、其制备方法及其医药用途。具体而言,本发明涉及一种通式(I)所示的新的喹啉类化合物、其制备方法,以及其作为多种蛋白激酶抑制剂的用途,特别是在预防和/或治疗癌症中的用途,其中,通式(I)中各基团的定义与说明书中的定义相同。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)