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1. (WO2018145620) SULPHAMOYLARYL DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF LIVER FIBROSIS

Pub. No.:    WO/2018/145620    International Application No.:    PCT/CN2018/075362
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Wed Feb 07 00:59:59 CET 2018
IPC: A61K 31/165
A61K 31/18
A61P 1/16
C07C 311/16
Applicants: JANSSEN PHARMACEUTICA NV
JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.
Inventors: WAN, Zhao-Kui
GUO, Haibing
VANDYCK, Koen
RABOISSON, Pierre
TAHRI, Abdellah
Title: SULPHAMOYLARYL DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF LIVER FIBROSIS
Abstract:
Potent 5-HT2B antagonist of Formula (A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof and their use wherein R1 to R4 and Ar have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them, alone or in combination with other drugs, in fibrosis and/or cirrhosis prevention or therapy.