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1. (WO2018145182) HYBRID PEPTIDE, SET OF HYBRID PEPTIDES, COMPOSITION, USES OF THE HYBRID PEPTIDE, METHOD FOR INDUCING AN IMMUNE RESPONSE AND KITS

Pub. No.:    WO/2018/145182    International Application No.:    PCT/BR2018/050024
Publication Date: Fri Aug 17 01:59:59 CEST 2018 International Filing Date: Sat Feb 10 00:59:59 CET 2018
IPC: C07K 19/00
A61K 39/116
G01N 33/569
Applicants: BIOTICK PESQUISA E DESENVOLVIMENTO TECNOLÓGICO LTDA.
FUNDAÇÃO BUTANTAN
Inventors: CHUDZINSKI-TAVASSI, Ana Marisa
DA SILVA, Bárbara Athayde Vaz Galvão
PASQUALOTO, Kerly Fernanda Mesquita
IWAI, Leo Kei
PORTO, Rafael Marques
Title: HYBRID PEPTIDE, SET OF HYBRID PEPTIDES, COMPOSITION, USES OF THE HYBRID PEPTIDE, METHOD FOR INDUCING AN IMMUNE RESPONSE AND KITS
Abstract:
The present invention relates to novel hybrid peptides, developed by combining peptide fragments from membrane surface proteins present in microorganisms that cause anaplasmosis, and in particular, bacteria of the species Anaplasma marginale. The present invention further relates to sets of hybrid peptides, to compositions and kits comprising said novel hybrid peptides, to uses thereof and to methods for inducing an immune response. Each hybrid peptide, according to the present invention, comprises two or more peptide fragments of the aminoacid sequences, as defined in the present invention, linked to each other by means of a spacer element. The peptide fragments combined are peptide fragments from the proteins MSP1, MSP1a, MSP1b, MSP2, MSP2-HRV, MSP3, OMP7, OMP8, VirB9 and VirB10.