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1. (WO2018145033) ONCOLYTIC VIRUS THERAPY

Pub. No.:    WO/2018/145033    International Application No.:    PCT/US2018/016912
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Tue Feb 06 00:59:59 CET 2018
IPC: C07K 14/47
C07K 14/52
C12N 7/01
C12N 15/09
Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors: GUO, Zong, Sheng
BARTLETT, David
LIU, Zuqiang
FEIST, Mathilde
Title: ONCOLYTIC VIRUS THERAPY
Abstract:
The presently disclosed subject matter relates to tumor infiltrated T cells induced by oncolytic virus ("OV-induced T cells"), methods of making and using said OV-induced T cells for an adoptive T-cell therapy. The presently disclosed subject matter further relates to oncolytic viruses and armed oncolytic viruses, methods of making and using said oncolytic viruses, as well as pharmaceutical compositions and kits comprising said oncolytic viruses.