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1. (WO2018144999) TARGETED ENGINEERED INTERFERON AND USES THEREOF

Pub. No.:    WO/2018/144999    International Application No.:    PCT/US2018/016857
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Tue Feb 06 00:59:59 CET 2018
IPC: A61K 38/00
A61K 38/21
C07K 14/52
C07K 14/555
C12N 15/09
Applicants: ORIONIS BIOSCIENCES, INC.
ORIONIS BIOSCIENCES NV
Inventors: KLEY, Nikolai
ZABEAU, Lennart
TAVERNIER, Jan
Title: TARGETED ENGINEERED INTERFERON AND USES THEREOF
Abstract:
The present invention relates to chimeric proteins comprising a consensus interferon as a signaling agent. In some embodiments, the consensus interferon is modified and comprises one or more mutations. In an embodiment, the modified consensus interferon comprise one or more mutations that reduce its affinity for IFNAR1 and comprises one or more mutations that reduce its affinity for IFNAR2. The present invention provides pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases. The present invention relates to a method for treating cancer, comprising administering an effective amount of the chimeric protein.