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1. (WO2018144966) BIOCONJUGATION METHODS FOR TARGETED IN SITU THERAPEUTIC DELIVERY

Pub. No.:    WO/2018/144966    International Application No.:    PCT/US2018/016791
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Tue Feb 06 00:59:59 CET 2018
IPC: A61K 47/55
A61K 47/69
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
THE U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Inventors: MYUNG, David
FERNANDES-CUNHA, Gabriella
LEE, Hyun, Jong
Title: BIOCONJUGATION METHODS FOR TARGETED IN SITU THERAPEUTIC DELIVERY
Abstract:
Bioconjugation methods for promoting wound healing are disclosed. In particular, the invention relates to the in situ application of non-photochemical crosslinking techniques such as copper-free click chemistry using strain-promoted azide-alkyne cycloaddition (SPAAC) or multi-functional succinimidyl esters as a therapeutic delivery modality for biomolecules and stem cells to enhance wound healing.