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1. (WO2018144949) OPTICAL SECTIONING

Pub. No.:    WO/2018/144949    International Application No.:    PCT/US2018/016750
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: G02B 21/06
G02B 21/36
G02B 27/58
Applicants: NORTHEASTERN UNIVERSITY
Inventors: HOFFMAN, Zachary, R.
DIMARZIO, Charles, A.
Title: OPTICAL SECTIONING
Abstract:
Methods, systems, and devices described herein enable single-image optical sectioning, even at depth within turbid media, such as human skin or other tissue. Embodiments can eliminate the need for multiple image samples or raster scans, making in-vivo or live biological imaging easier and faster than multi-image sectioning techniques. Better contrast and resolution than traditional three-phase structured illumination microscopy (SIM) is possible in turbid media. Embodiments enable imaging of cell nuclei. Resolution and contrast resulting from disclosed embodiments are less sensitive to motion of or within patients or other targets than confocal microscopy and three-phase SIM techniques. Three-dimensional images of target specimens can be provided based on a group of single-image optical sections. Real-time imaging can also be provided.