Search International and National Patent Collections

1. (WO2018144935) COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA

Pub. No.:    WO/2018/144935    International Application No.:    PCT/US2018/016727
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: A61K 48/00
C12N 15/11
C12N 15/113
Applicants: CITY OF HOPE
Inventors: MORRIS, Kevin, V.
RAY, Roslyn
Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA
Abstract:
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia. The compositions include double-stranded and single-stranded RNAs capable of repressing IncRNA and concomitantly increasing LDLR activation. The compositions are useful for activating LDLR in liver cells.