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1. (WO2018144935) COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/144935 International Application No.: PCT/US2018/016727
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
A61K 48/00 (2006.01) ,C12N 15/11 (2006.01) ,C12N 15/113 (2010.01)
Applicants: CITY OF HOPE[US/US]; 1500 E. Duarte Road Duarte, CA 91010-3000, US
Inventors: MORRIS, Kevin, V.; US
RAY, Roslyn; US
Agent: HETZER, Claudia; US
AZRIN, Linda, B.; US
ADAMS, Lisa; US
BAUER, John, A.; US
AMENDT, Kevin, C.; US
Priority Data:
62/454,62903.02.2017US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA
(FR) COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE L'HYPERCHOLESTÉROLÉMIE
Abstract: front page image
(EN) Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia. The compositions include double-stranded and single-stranded RNAs capable of repressing IncRNA and concomitantly increasing LDLR activation. The compositions are useful for activating LDLR in liver cells.
(FR) La présente invention concerne des compositions et des méthodes pour le traitement de l'hypercholestérolémie. Les compositions comprennent des ARN à bicaténaires et monocaténaires capables de réprimer l'ARNlnc et d'augmenter simultanément l'activation de LDLR. Les compositions sont utiles pour activer le LDLR dans des cellules hépatiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)