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1. (WO2018144886) HYDROPORPHYRINS FOR PHOTOACOUSTIC IMAGING

Pub. No.:    WO/2018/144886    International Application No.:    PCT/US2018/016672
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: C07D 487/22
G01N 21/64
Applicants: NIRVANA SCIENCES
Inventors: PITNER, James Bruce
RAJAMAHENDIRAN, Rajalekha Manjakuppam
THOMAS, Russell D
Title: HYDROPORPHYRINS FOR PHOTOACOUSTIC IMAGING
Abstract:
Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a bacteriochlorin, a metallobacteriochlorin, a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed bacteriochlorins, metallobacteriochlorins, and/or derivatives thereof simultaneously.