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1. (WO2018144880) NEW PEPTIDE-LINKED ESTER PRODRUGS ACTIVATED BY PROSTATE-SPECIFIC ANTIGEN
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Pub. No.: WO/2018/144880 International Application No.: PCT/US2018/016665
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
C07K 7/02 (2006.01) ,A61K 31/351 (2006.01)
[IPC code unknown for C07K 7/02][IPC code unknown for A61K 31/351]
Applicants:
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; Old Queen's, Somerset Street New Brunswick, New Jersey 08901, US
Inventors:
HU, Longqin; US
ALOYSIUS, Herve; US
Agent:
GORMAN, Susan; US
Priority Data:
62/454,24403.02.2017US
Title (EN) NEW PEPTIDE-LINKED ESTER PRODRUGS ACTIVATED BY PROSTATE-SPECIFIC ANTIGEN
(FR) NOUVEAUX PROMÉDICAMENTS D'ESTER À LIAISON PEPTIDIQUE ACTIVÉS PAR UN ANTIGÈNE SPÉCIFIQUE DE LA PROSTATE
Abstract:
(EN) The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.
(FR) La présente invention concerne une série de promédicaments d'esters chimiothérapeutiques sélectifs cibles comprenant des peptides clivables par PSA qui favorisent l'administration de la doxorubicine libre et d'autres agents chimiothérapeutiques dans la prostate et/ou dans les tumeurs de la prostate avec une plus grande efficacité.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)