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1. (WO2018144832) METHODS FOR MEASURING SMALL MOLECULE AFFINITY TO CEREBLON

Pub. No.:    WO/2018/144832    International Application No.:    PCT/US2018/016609
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Sat Feb 03 00:59:59 CET 2018
IPC: G01N 33/50
C07K 16/18
C12Q 1/68
Applicants: CELGENE CORPORATION
Inventors: CHAMBERLAIN, Philip Paul
MATYSKIELA, Mary
KHAMBATTA, Godrej
Title: METHODS FOR MEASURING SMALL MOLECULE AFFINITY TO CEREBLON
Abstract:
A complex comprises a CRBN having a europium-anti-his antibody on the N-terminus of the CRBN, and a Cy5-conjugated small molecule, wherein the Cy5-conjugated small molecule binds the CRBN, and uses thereof for identifying therapeutic compounds.