Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018144816) METABOLIC BIOMARKERS FOR COGNITIVE ABILITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/144816 International Application No.: PCT/US2018/016590
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
G01N 33/48 (2006.01) ,G01N 33/50 (2006.01) ,A61P 25/28 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
GEORGETOWN UNIVERSITY [US/US]; 37th and O Streets, N.W. Washington, District of Columbia 20057, US
UNIVERSITY OF ROCHESTER [US/US]; 601 Elmwood Avenue, Box URV Rochester, New York 14642, US
Inventors:
MAPSTONE, Mark E.; US
FEDEROFF, Howard J.; US
FIANDACA, Massimo S.; US
CHEEMA, Amrita K.; US
Agent:
BUCK, Todd B.; US
SMYTH, Robert J.; US
LOWEN, Gregory T.; US
LEE, Janice H.; US
Priority Data:
62/453,74202.02.2017US
Title (EN) METABOLIC BIOMARKERS FOR COGNITIVE ABILITY
(FR) BIOMARQUEURS MÉTABOLIQUES DE LA CAPACITÉ COGNITIVE
Abstract:
(EN) The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.
(FR) La présente invention concerne des procédés permettant de déterminer si un sujet présente un risque moins important d'être atteint de troubles de la mémoire dans le futur. Ces méthodes comprennent l’analyse d’au moins un échantillon de plasma prélevé chez le sujet pour déterminer la valeur du profil métabolique du sujet, et la comparaison de la valeur du profil métabolique du sujet à la valeur d'un profil métabolique normal. Une modification de la valeur du profil métabolique du sujet par rapport à des valeurs normales indique que le sujet présente un risque moins important d'être atteint dans le futur de troubles de la mémoire par rapport à un sujet normal.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)