Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018144791) COMBINATION OF VPS34 INHIBITORS AND MTOR INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/144791 International Application No.: PCT/US2018/016552
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
A61P 11/06 (2006.01) ,A61P 17/06 (2006.01) ,C07D 213/76 (2006.01) ,C07D 405/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
76
to which a second hetero atom is attached
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
MILLENNIUM PHARMACEUTICALS, INC. [US/US]; 40 Landsdowne Street Cambridge, MA 02139, US
Inventors:
CHOUITAR, Jouhara; US
D'AMORE, Natalie, Roy; US
LEE, Janice; US
Agent:
LOU, Changgang; US
YEUNG, Constance; US
CLOUTIER, Mario; US
HORWITTZ, Lillian, R.; US
SIOUSSAT, Tracy, M.; US
Priority Data:
62/454,33003.02.2017US
Title (EN) COMBINATION OF VPS34 INHIBITORS AND MTOR INHIBITORS
(FR) COMBINAISON D'INHIBITEURS DE VPS34 ET D'INHIBITEURS DE MTOR
Abstract:
(EN) Disclosed are methods for the treatment of cancer in patients in need of such treatment. The methods comprise administering to such a patient a VPS34 inhibitor such as is N-{6-chloro-4-methyl-2'- [(2-methylpyrimidin-4-yl)amino]-3,4'-bipyridin-5-yl} -2,4-difluorobenzenesulfonamide or a pharmaceutically acceptable salt in combination with an mTOR inhibitor. Also disclosed are medicaments for use in the treatment of cancer.
(FR) La présente invention concerne des méthodes pour le traitement du cancer chez des patients en attente d'un tel traitement. Les méthodes comprennent l'administration à un tel patient d'un inhibiteur de VPS34 tel que le N-{6-chloro-4-méthyl-2'-[(2-méthylpyrimidin-4-yl)amino]-3,4'-bipyridin-5-yl} -2,4-difluorobenzènesulfonamide ou un sel pharmaceutiquement acceptable en combinaison avec un inhibiteur de mTOR. L'invention concerne également des médicaments destinés à être utilisés dans le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)