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Machine translation
1. (WO2018144789) FUSED 1,4-DIAZEPINES AS BET BROMODOMAIN INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/144789 International Application No.: PCT/US2018/016549
Publication Date: 09.08.2018 International Filing Date: 02.02.2018
IPC:
C07D 487/04 (2006.01) ,C07D 495/14 (2006.01) ,C07D 498/04 (2006.01) ,C07D 498/12 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/12 (2006.01) ,A61K 31/424 (2006.01) ,A61K 31/55 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN[US/US]; Office of Technology Transfer 1600 Huron Parkway, 2nd Floor Ann Arbor, MI 48109-2590, US
Inventors: WANG, Shaomeng; US
HU, Jiantao; US
XU, Fuming; US
Agent: NAPOLI, James, J.; US
Priority Data:
62/454,25703.02.2017US
Title (EN) FUSED 1,4-DIAZEPINES AS BET BROMODOMAIN INHIBITORS
(FR) 1,4-DIAZÉPINES FUSIONNÉES UTILISÉES EN TANT QU'INHIBITEURS DE BROMODOMAINES BET
Abstract: front page image
(EN) The present disclosure provides fused 1,4-diazepines represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, E, R1, R2, R3, R4, R5, and Ar are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds having Formula (I) to treat diseases, conditions, or disorders responsive to inhibition of BET bromodomain proteins such as cancer.
(FR) La présente invention concerne des 1,4-diazépines fusionnées représentées par la formule (I) : et des sels et solvates pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), A, E, R1, R2, R3, R4, R5 et Ar sont tels que définis dans la description. La présente invention concerne également l'utilisation des composés de formule (I) pour le traitement de maladies, d'états pathologiques ou de troubles sensibles à l'inhibition de bromodomaines BET tel que le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)