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1. (WO2018144775) IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES
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Pub. No.: WO/2018/144775 International Application No.: PCT/US2018/016510
Publication Date: 09.08.2018 International Filing Date: 01.02.2018
IPC:
A61K 39/00 (2006.01) ,A61K 39/39 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
Applicants:
MODERNATX, INC. [US/US]; 200 Technology Square Cambridge, MA 02139, US
Inventors:
HUANG, Eric Yi-chun; US
TSE, Sze-Wah; US
IACOVELLI, Jared; US
MCKINNEY, Kristine; US
VALIANTE, Nicholas; US
Agent:
MANDRAGOURAS, Amy, E.; US
CANNING, Kevin, J.; US
BRULEY, Kenneth, C.; US
DUKES, Mark, C.; US
DIGIORGIO, Jeanne, M.; US
Priority Data:
62/453,46501.02.2017US
62/467,06303.03.2017US
62/490,52326.04.2017US
62/541,57104.08.2017US
Title (EN) IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES
(FR) COMPOSITIONS THÉRAPEUTIQUES IMMUNOMODULATRICES D'ARNM CODANT POUR DES PEPTIDES DE MUTATION D'ACTIVATION D'ONCOGÈNES
Abstract:
(EN) The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
(FR) La présente invention concerne des compositions thérapeutiques immunomodulatrices d'un ARNm codant pour un peptide de mutation d'activation d'oncogènes et d'un ARNm codant pour un polypeptide qui améliore les réponses immunitaires contre le peptide de mutation d'activation d'oncogènes, par exemple un ARNm codant pour un potentialisateur d'immunité. L'invention concerne également des méthodes d'utilisation de celles-ci, par exemple, pour stimuler des réponses immunitaires anti-cancéreuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)