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1. (WO2018144677) COMPOSITIONS AND METHODS FOR REDUCING MUSCLE CONTRACTION
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Pub. No.: WO/2018/144677 International Application No.: PCT/US2018/016355
Publication Date: 09.08.2018 International Filing Date: 01.02.2018
IPC:
A61K 31/15 (2006.01) ,A61K 31/4425 (2006.01) ,A61K 45/06 (2006.01) ,A61P 43/00 (2006.01) ,A61P 21/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
15
Oximes (CN-O-); Hydrazines (N-N); Hydrazones (N-N)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4425
Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
02
Muscle relaxants, e.g. for tetanus or cramps
Applicants:
BRIGHT, Jessica, Catherine [US/US]; US
BATTELLE MEMORIAL INSTITUTE [US/US]; 505 King Avenue Columbus, OH 43201, US
Inventors:
BRIGHT, Jessica, Catherine; US
BURBACK, Brian; US
JOHNSON, Jerry, D.; US
Agent:
TEPE, Nicole, M.; US
GOLDSTEIN, Steven, J.; US
MORRISS, William, S.; US
ULMER, Andrew, B.; US
VISCONTE, Barry; US
Priority Data:
62/453,58202.02.2017US
Title (EN) COMPOSITIONS AND METHODS FOR REDUCING MUSCLE CONTRACTION
(FR) COMPOSITIONS ET PROCÉDÉS DE RÉDUCTION DE LA CONTRACTION MUSCULAIRE
Abstract:
(EN) Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction/neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed.
(FR) L'invention concerne des procédés de réduction de la contraction musculaire dans un diaphragme ou un muscle(s) périphérique(s) d'un patient suffisant pour permettre une intervention chirurgicale. Les procédés peuvent comprendre l'étape d'administration d'une oxime ou d'un sel pharmaceutiquement acceptable de celle-ci à un sujet en ayant besoin en une quantité suffisante pour atteindre ledit blocage neuromusculaire/contraction musculaire réduit. L'invention concerne également des kits et des articles de fabrication comprenant un récipient ayant une étiquette et une composition.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)