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1. (WO2018144675) ENGINEERED GLYCOSYLTRANSFERASES AND STEVIOL GLYCOSIDE GLUCOSYLATION METHODS
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Pub. No.: WO/2018/144675 International Application No.: PCT/US2018/016352
Publication Date: 09.08.2018 International Filing Date: 01.02.2018
IPC:
C12P 19/56 (2006.01) ,C12N 9/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
44
Preparation of O-glycosides, e.g. glucosides
56
having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
Applicants:
CODEXIS, INC. [US/US]; 200 Penobscot Drive Redwood City, CA 94063, US
Inventors:
VROOM, Jonathan; US
GALANIE, Stephanie, Sue; US
DELLAS, Nikki; US
LIANG, Jack; US
LIU, Joyce; US
ENTWISTLE, David; US
MOFFETT, Courtney, Dianne; US
Agent:
MACKNIGHT, Kamrin, T.; US
Priority Data:
62/454,41703.02.2017US
62/479,26230.03.2017US
Title (EN) ENGINEERED GLYCOSYLTRANSFERASES AND STEVIOL GLYCOSIDE GLUCOSYLATION METHODS
(FR) GLYCOSYLTRANSFÉRASES MODIFIÉES ET PROCÉDÉS DE GLUCOSYLATION DE GLYCOSIDES DE STÉVIOL
Abstract:
(EN) The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
(FR) L'invention concerne des enzymes glycosyltransférases (GT) modifiées, des polypeptides dotés d'une activité GT et des polynucléotides codant pour ces enzymes, ainsi que des vecteurs et des cellules hôtes contenant lesdits polynucléotides et polypeptides. L'invention concerne également des enzymes de sucrose synthase (SuS) modifiées, des polypeptides dotés d'une activité SuS et des polynucléotides codant pour ces enzymes, ainsi que des vecteurs et des cellules hôtes contenant lesdits polynucléotides et polypeptides. L'invention concerne encore des compositions comprenant ces enzymes GT et des procédés d'utilisation des enzymes GT modifiées pour fabriquer des produits à liaisons β-glucose. L'invention concerne également des compositions comprenant les enzymes SuS, ainsi que des procédés d'utilisation associés. L'invention concerne encore des procédés de production d'enzymes GT et SuS.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)