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1. (WO2018144620) ANTI-FIBROTIC COMPOUNDS

Pub. No.:    WO/2018/144620    International Application No.:    PCT/US2018/016272
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Thu Feb 01 00:59:59 CET 2018
IPC: C07C 235/38
A61K 31/167
A61P 17/00
C07C 235/40
C07C 237/20
C07C 255/60
C07D 205/04
C07D 207/12
C07D 207/24
C07D 209/46
C07D 211/22
C07D 211/26
C07D 211/46
C07D 211/58
C07D 213/30
Applicants: SHIRE HUMAN GENETIC THERAPIES, INC.
Inventors: MILLER, Thomas
PAPAIOANNOU, Nikolaos
Title: ANTI-FIBROTIC COMPOUNDS
Abstract:
Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. (Formula (I))