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1. (WO2018144597) METHODS OF SENSITIZING CANCER CELLS TO IMMUNE CELL KILLING

Pub. No.:    WO/2018/144597    International Application No.:    PCT/US2018/016230
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Thu Feb 01 00:59:59 CET 2018
IPC: C12N 9/12
C12Q 1/68
G01N 33/50
Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors: VOGT, Andreas
KALTENMEIER, Christof, Tobias
LOTZE, Michael, T.
TSANG, Waikok, Michael
Title: METHODS OF SENSITIZING CANCER CELLS TO IMMUNE CELL KILLING
Abstract:
The presently disclosed subject matter is directed to dual specificity mitogen-activated protein kinase phosphatase (DUSP-MKP) inhibitors that sensitize cancer cells immune cell killing and methods of using the disclosed DUSP-MKP inhibitors for the treatment of cancer.