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1. (WO2018144556) COMPOSITIONS AND METHODS FOR INHIBITING SHEAR-INDUCED PLATELET ACCUMULATION

Pub. No.:    WO/2018/144556    International Application No.:    PCT/US2018/016165
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Thu Feb 01 00:59:59 CET 2018
IPC: A61K 31/765
A61K 9/14
A61K 31/74
A61K 47/34
Applicants: GEORGIA TECH RESEARCH CORPORATION
Inventors: GRIFFIN, Michael, T.
AIDUN, Cyrus, K.
KU, David, N.
Title: COMPOSITIONS AND METHODS FOR INHIBITING SHEAR-INDUCED PLATELET ACCUMULATION
Abstract:
Methods of modulating the conformation of vWF are provided. One embodiment provides a method for linearizing globular vWF by contacting globular vWF proteins with an effective amount of negatively charged nanoparticles that interact with the globular vWF proteins to induce a conformational change in the globular vWF proteins such that the change in conformation inhibits or reduces the ability of the vWF proteins to bind to platelet receptors. Preferred negatively charged nanoparticles are non- functionalized.