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1. (WO2018144506) HARVESTING CELL-FREE NON-CODING RNAS (CFNCRS) FROM INTERSTITIAL FLUID FOR SENSITIVE BIOMARKERS

Pub. No.:    WO/2018/144506    International Application No.:    PCT/US2018/016083
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Thu Feb 01 00:59:59 CET 2018
IPC: G01N 33/50
C07H 21/02
C12Q 1/68
A61B 5/15
A61B 5/1477
C12N 15/113
Applicants: GEORGETOWN UNIVERSITY
Inventors: PARANJAPE, Makarand
Title: HARVESTING CELL-FREE NON-CODING RNAS (CFNCRS) FROM INTERSTITIAL FLUID FOR SENSITIVE BIOMARKERS
Abstract:
A system for determining the presence of cell-free non-coding RNA (cfNCR) biomarkers in interstitial fluid includes a microfluidic device for non-invasively and passively accessing interstitial fluid from a patient. The microfluidic device is formed of a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.