Search International and National Patent Collections

1. (WO2018144481) MULTI-ARM BLOCK-COPOLYMERS FOR MULTIFUNCTIONAL SELF-ASSEMBLED SYSTEMS

Pub. No.:    WO/2018/144481    International Application No.:    PCT/US2018/016016
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Wed Jan 31 00:59:59 CET 2018
IPC: C09D 181/02
C08L 71/08
C08L 81/02
C09D 171/08
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: SEGURA, Tatiana
BERNTHAL, Nicholas
XI, Weixian
Title: MULTI-ARM BLOCK-COPOLYMERS FOR MULTIFUNCTIONAL SELF-ASSEMBLED SYSTEMS
Abstract:
A copolymer poly(ethylene glycol)-polyallyl mercaptan (PEG-PAM) material is used as a drug-containing coating for medical implants. In one embodiment, a mixture of multi-arm poly(ethylene glycol) (PEG), polyallyl mercaptan (PAM), a photoinitiator, organic solvent, and one or more drugs, medicaments, or pharmaceutical compounds is applied to a surface of the implant and is exposed to a polymerizing light source to form a PEG-PAM material coating that is formed in situ on the implant. The PEG-PAM coating may be used by surgeons to incorporate antibacterial drugs or the like into coatings that are applied in the operating room setting to medical devices such as orthopedic implants. The type of drug and dosing can be customized during the coating operation and tailored to the patient's needs. PEG-PAM may also be applied as a coating on or within tissue or an injectable gel.