WO2018144438 METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F

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Publication Number WO/2018/144438

Publication Date 09.08.2018

International Application No. PCT/US2018/015905

International Filing Date 30.01.2018

IPC

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Applicants

MERCK SHARP & DOHME CORP. [US]/[US]
WINTERS, Michael Albert [US]/[US] (US)
MACNAIR, John, E. [US]/[US] (US)

Inventors

WINTERS, Michael Albert
MACNAIR, John, E.

Common Representative

MERCK SHARP & DOHME CORP.

Priority Data

62/452,521

31.01.2017

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F

(FR) PROCÉDÉS DE PRODUCTION DE CONJUGUÉS PROTÉINE-POLYSACCHARIDE CAPSULAIRE À PARTIR DU SÉROTYPE 19F DE STREPTOCOCCUS PNEUMONIAE

Abstract

(EN) The present invention provides a method of producing a polysaccharide - protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation step prior to filtration to remove free polysaccharide.

(FR) La présente invention concerne un procédé de production d'un conjugué polysaccharide-protéine avec un polysaccharide capsulaire à partir du sérotype 19F de Streptococcus pneumoniae conjugué à une protéine porteuse. Le procédé comprend une étape d'incubation prolongée avant la filtration pour éliminer le polysaccharide libre.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
74	Bacteria

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
02	Bacterial antigens

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
02	Bacterial antigens
09	Streptococcus

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
39	characterised by the immunostimulating additives, e.g. chemical adjuvants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
385	Haptens or antigens, bound to carriers

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1. WO2018144438 - METHODS FOR PRODUCTION OF CAPSULAR POLYSACCHARIDE PROTEIN CONJUGATES FROM STREPTOCOCCUS PNEUMONIAE SEROTYPE 19F

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195	from bacteria
315	from Streptococcus (G), e.g. Enterococci

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
195	from bacteria
315	from Streptococcus (G), e.g. Enterococci

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36	Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36	Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
56	the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
61	the organic macromolecular compound being a polysaccharide or a derivative thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
17	Carrier-bound or immobilised peptides; Preparation thereof
02	Peptides being immobilised on, or in, an organic carrier
10	the carrier being a carbohydrate