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1. (WO2018144425) GENERATION OF HUMAN ALLERGEN-AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE

Pub. No.:    WO/2018/144425    International Application No.:    PCT/US2018/015870
Publication Date: Fri Aug 10 01:59:59 CEST 2018 International Filing Date: Wed Jan 31 00:59:59 CET 2018
IPC: A61K 35/28
A61K 39/00
A61K 39/395
Applicants: VANDERBILT UNIVERSITY
Inventors: SMITH, Scott, A.
Title: GENERATION OF HUMAN ALLERGEN-AND HELMINTH-SPECIFIC IGE MONOCLONAL ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
Abstract:
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.