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1. (WO2018143874) METHODS FOR IDENTIFYING NEW THERAPEUTIC AGENTS
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Pub. No.: WO/2018/143874 International Application No.: PCT/SE2018/050066
Publication Date: 09.08.2018 International Filing Date: 30.01.2018
IPC:
G01N 33/569 (2006.01) ,C12N 15/113 (2010.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
YOUNIS, Shady [SE/SE]; SE
KEMAL, Wael [SE/SE]; SE
AKUSJÄRVI, Göran [SE/SE]; SE
ANDERSSON, Leif [SE/SE]; SE
Inventors:
YOUNIS, Shady; SE
KEMAL, Wael; SE
AKUSJÄRVI, Göran; SE
ANDERSSON, Leif; SE
Agent:
BERGMAN, Anders; SE
Priority Data:
1730023-731.01.2017SE
Title (EN) METHODS FOR IDENTIFYING NEW THERAPEUTIC AGENTS
(FR) PROCÉDÉ D’IDENTIFICATION DE NOUVEAUX AGENTS THÉRAPEUTIQUES
Abstract:
(EN) The present invention relates to methods for identifying therapeutic agents capable of modulating the activity of the nuclear protein ZC3H11A (zinc finger CCCH-type containing 11A). Such agents will find use in the treatment, prophylaxis and prevention of viral diseases. The invention further relates RNAi molecules and antisense polynucleotide complementary to a polynucleotide sequence encoding ZC3H11A for use in the prevention, prophylaxis and/or treatment of a viral diseases.
(FR) La présente invention porte sur procédé d’identification d’agents thérapeutiques pouvant moduler l’activité de la nucléoprotéine ZC3H11A (type CCCH à doigt à zinc contenant du 11A). De tels agents trouveront un usage dans le traitement, la prophylaxie et la prévention de maladies virales. L’invention porte en outre sur des molécules d’ARNi et sur des polynucléotides antisens complémentaires à une séquence de polynucléotides codant la ZC3H11A utilisables dans la prévention, la prophylaxie et/ou le traitement de maladies virales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)